邹美娟/副教授

邹美娟/副教授

程序性细胞死亡在肿瘤发生与干预中的分子机制

教育经历

2008.09-2013.06   中国药科大学，肿瘤药理学、微生物与生化药学，硕博连读

工作经历

2017.09-2021.05   美国匹兹堡大学医学中心（UPMC），病理系和衰老研究所，博士后研究

2018.06-至今      南京医科大学，基础医学院药理系，副教授

2013.09-2018.06 南京医科大学，基础医学院药理系，讲师

研究经历

（1）    运用CRISPR-Cas9介导的全基因组筛选系统鉴定转录因子及其对肿瘤发生和干预的功能调节。

（2）    运用CRISPR-Cas9基因组编辑技术，靶向被鉴定为致癌驱动因子的融合基因的breakpoint，插入自杀基因，研究实体肿瘤的基因靶向治疗。

（3）    基于全基因组关联研究（GWAS）和二代测序技术（NGS），运用SNP-Seq和Reel-seq技术快速鉴定和验证与疾病相关的功能性SNP介导的转录调控网络研究。

（4）    衰老，自噬在肿瘤侵袭和转移中作用的分子细胞生物学机制研究。

（5）    幽门螺杆菌新毒素介导的DNA甲基化促进炎癌转化的机制。

（6）    MicroRNA在细胞自噬，纤维化，炎癌转化中的调控研究。

（7）    基于自噬性细胞死亡在抗肿瘤药物（小分子和天然产物）中的筛选和作用机制研究。

发表学术论文

1. Song-Yu Wu, Ya-Xi Ye, Qing Zhang, Qian-Jin Kang, Zhu-Min Xu, Shen-Zhen Ren, Yong-Tao Duan, Fan Lin, Haojun Xu, Ziyi Hu, Suisui Yang, Hai-Liang Zhu*, Meijuan Zou* (Corresponding author), Zhong-Chang Wang*. Multifunctional Protein Hybrid Nanoplatform for Synergetic Photodynamic-Chemotherapy of Malignant Carcinoma by Homologous Targeting Combined with Oxygen Transport. Advanced Science. Accepted on 2022 Dec 01. DOI: 10.1002/advs.202203742.

2.Jingjing Wu, Changying Xing, Li Zhang, Huijuan Mao, Xuguan Chen, Mingxing Liang, Fang Wang, Haibin Ren, Hongqing Cui, Aiqin Jiang, Zibin Wang, Meijuan Zou* (Corresponding author), Yong Ji*. Autophagy promotes fibrosis and apoptosis in the peritoneum during longterm peritoneal dialysis. Journal of Cellular Molecular Medicine. 2018 Feb; 22(2): 1190-1201.

3.Meijuan Zou* (Responding author), Wei Zhu, Li Wang, Lei Shi, Rui Gao, Yingwei Ou, Xuguan Chen, Zhongchang Wang, Aiqin Jiang, Kunmei Liu, Ming Xiao, Ping Ni, Dandan Wu, Wenping He, Geng Sun, Ping Li, Sulan Zhai, Xuerong Wang, Gang Hu. AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition. Oncotarget. 2016 Mar 15;7(11):13122-38.

4.Meijuan Zou* (Corresponding author), YongTao Duan, Pengfei Wang, Rui Gao, Xuguan Chen, Yingwei Ou, Mingxing Liang, Zhongchang Wang, Yi Yuan, Li Wang, Hailiang Zhu. DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion via inhibition of AEG-1 and NF-κB signaling pathway. Scientific Reports. 2016 Jun 2;6:27331.

5.Yong-Tao Duan, Ruo-Jun Man, Dan-Jie Tang, Yong-Fang Yao, Xiang-Xiang Tao, Chen Yu, Xin-Yi Liang, Meijuan Zou* (Corresponding author), Zhong-Chang Wang,

Jigar A. Makawana, Hailiang Zhu*. Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent

Antitubulin Agents. Scientific Reports. 2016 May 3;6:25387.

6.Meijuan Zou, Danli Jiang, Ting Wu, Xiaoyu Zhang, Yihan Zhao, DiWu, Wei Sun, Jing Cui, Larry Moreland, Gang Li. Post-GWAS functional studiesreveal an RA-associated CD40induced NFkB signal transduction andtranscriptional regulation network targeted by class II HDAC inhibitors. Human Molecular Genetics. 2021 May 28;30(9):823-835.

7.Meijuan Zou, Xiaoyu Zhang, Danli Jiang, Yihan Zhao, Ting Wu,Qiaoke Gong, Hang Su, Di Wu, Larry Moreland, and Gang Li. TranscriptionalRegulation of CD40 Expression by 4 Ribosomal Proteins via a Functional SNP on aDisease-Associated CD40 Locus. Genes(Basel). 2020 Dec;11(12): 1526.

8.Meijuan Zou, Fang Wang, Aiqin Jiang, Anliang Xia, Siya Kong, Chun Gong, Mingxia Zhu, Xin Zhou, Jun Zhu, Wei Zhu, Wenfang Cheng. MicroRNA-3178ameliorates inflammation and gastric carcinogenesispromoted by Helicobacter pylori new toxin, Tip-α,by targeting TRAF3.Helicobacter. 2017 Apr;22(2).